How To Unlock The True Anti-Aging Power Of Hyaluronic Acid

By Lisa Jones Dec 01, 20

Hyaluronic acid is one of the most popular skincare ingredients today. According to many top dermatologists, Hyaluronic acid injections should be your top choice if you want smooth, supple skin with less visible wrinkles and lines.

But how effective is hyaluronic acid in topical products?

Shopping for products with hyaluronic acid can be confusing. The market is teeming with products containing hyaluronic acid, priced anywhere from $6 to more than $300 for the same 30ml bottle. Studies warn that many hyaluronic acid products are a complete waste of money; oftentimes its molecules are too large to penetrate the skin. It’s hard to figure that out just by looking at the label.

Conversely, there are technologies that can intensify the effects of hyaluronic acid to deliver truly miraculous results that dermatologists are raving about. In this article we’ll tell you everything you need to know about hyaluronic acid, how to choose the right kind, and how to ensure that you get the most of its amazing benefits.


Hyaluronic acid a gooey substance that occurs naturally in the human body. Its main function of is to keep tissues lubricated and moist by retaining water. It is also found in the joints, where it keeps the space between the bones well lubricated, preventing your bones grinding against each other. However, half of the hyaluronic acid in our bodies is concentrated in our skin.  


Hyaluronic acid firms the skin and maintains hydration of the skin by attracting water. Hyaluronic acid binds to water, which hydrates the skin and gives it a glowing, dewy quality.”

A hyaluronic acid molecule can hold 1,000 times its weight in water. This makes hyaluronic acid nature’s most powerful moisturizer. The result? This hydration diminishes the appearance of wrinkles and lines, and promotes healthier, younger looking skin.


Studies show that hyaluronic acid reduces inflammation and repairs skin. It signals the body to build more blood vessels in the damaged area, which increases microcirculation and promotes healing. This promotes skin regeneration and renewal, which keeps the skin young.


Science has confirmed that the function of hyaluronic acid in our skin is beyond doubt. But that doesn’t mean that conventionally produced hyaluronic acid will have the same effect, especially when topically applied to the skin. When it comes to hyaluronic acid, size matters. Molecular size that is.

To avoid ever wasting money on ineffective hyaluronic acid products, take a look at the science behind them. Here’s a quote from a study: “The challenging characteristic of conventional HAs in the use of topically applied anti-aging preparations has been that its molecules are 3,000nm in diameter, whereas the intercellular space is only 15 to 50nm and just 6 to lOnm at the hyaline membrane. This makes it impossible for conventionally produced HA to penetrate into deep layers of the dermis.” So, it’s simply IMPOSSIBLE for many of these hyaluronic acid products to even penetrate your skin because they are too large.


Previously, if you wanted to get real results from hyaluronic acid, injections were pretty much the only way. But now, new cutting-edge technologies make it possible to produce nano-molecules of hyaluronic acid that can easily penetrate the skin. The same study found that topical applications of these products are incredibly effective on aging skin.

When you’re shopping for a topical hyaluronic acid product, it is important to know the size of the hyaluronic acid molecules used. If the label doesn’t provide this information, request it from the manufacturer. It’s an extra step, but it’s well worth it and will ensure that you are selecting a product that will be more effective.


Effects of Hyaluronic acid can be further enhanced through synergies with other substances. Hyaluronic acid plays well with other skincare ingredients, such as antioxidants. But studies found that combining hyaluronic acid with sodium succinate delivers the strongest one-two punch against skin aging. 

Sodium succinate is another naturally occurring substance in our body and is a key element for producing energy at the cellular level, balancing hormones, and controlling free radicals. Crucially, succinate activates Complex II SDH enzymes, which have been shown in a recent study to be the skin’s primary defense against free radicals.

“Hyaluronic acid works synergistically with sodium succinate to stimulate collagen growth and improve the structure and function of the dermis and blood vessels. Additionally, succinate is known to support robust function in stem cells, which are responsible for producing new skin cells”, says Dr. Boris Gorinshten, who formulates skincare products and spent years researching succinate.

In a recent skincare study, researchers found that this combination increased collagen-building activity by 300%, which is 100% more than hyaluronic acid alone. It also improved firmness, hydration, density, tone, pigmentation, and texture of the skin.

Until recently, this combination was only available in an injectable form. But now, thanks to a new technology developed by Key Element, a highly penetrable form of hyaluronic acid has been complexed with Axigen® (Sodium Succinate) for the first time in a topical serum.

You can learn more about Key Element skincare innovation here