Three Ways Perimenopause Can Permanently Ruin Your Skin

By Lisa Jones Dec 15, 20

After turning 40, many women begin to notice that their skin is becoming increasingly dry and sensitive. Aging signs, such as wrinkles and fine lines, seem to set in as well. It’s not unusual to find that your old approach to taking care of your skin stops working or even begins to irritate your skin.

According to the American Association of Dermatology, a woman’s skin loses the ability to hold water around perimenopause, so if you are experiencing persistent dryness, you may be entering this stage in your life.

It’s absolutely crucial to figure out the right skincare strategy early on. Because in the next few years, hormonal, and other changes in the body will affect the look of your skin profoundly. And, if left unchecked, permanently.

Here are 3 ways in which perimenopause can wreck your skin, and what you may be able to do about it.


Hormonal changes affect physiology of our skin, which leads to rapidly developing signs of aging, including:

  • Slack skin and wrinkles – Loss of hormonal balance will cause the loss of supportive fat below the skin of the face and neck. 
  • Oily skin – Sebaceous glands secrete thinker sebum, which may cause oily skin and adult acne. 
  • Loss of collagen and elastin – Estrogen partially controls synthesis of collagen and elastin, therefore, due to declining estrogen levels our skin loses the ability to produce and repair collagen and elastin. Most women lose up to 30% of collagen in the first 5 years of menopause. 
  • Hyperpigmentation/aging spots – Estrogen keeps melanin in check, so when estrogen is low, your body makes more melanin, brining your past exposure to UV light to the surface. 
  • Thinning skin – Without balanced hormones the body cannot build blood vessels as effectively to deliver oxygen and nutrients to the skin, which affects skin renewal and regeneration. 
  • Breakouts and acne - Some women are unpleasantly surprised that they can now get acne and wrinkles at the same time, but that’s what unbalance hormones do! 


Hormonal changes during perimenopause may also cause a number of symptoms, each of which can make your skin problems worse.

The most common symptoms include:

• Hot flashes and night sweats

• Difficulty sleeping

• Increased stress and mood changes

• Weight gain

• Low energy


In addition to hormonal troubles, our skin faces another major crisis – lower levels of a key enzyme called succinate dehydrogenase, or Complex II SDH. A breakthrough study at the Newcastle University discovered that this enzyme is our body’s first and main line of defense against free radicals. It’s also a major source of energy for our cells. Without the sufficient levels Complex II SDH, our skin cells can’t fight off free radicals. They become overwhelmed and deteriorate.

To help us explain the implications of this breakthrough discovery, we reached out to Dr. Sheila Krishna, MD., an MIT-trained dermatologist and clinical researcher. “The study showed that Complex II SDH plays a major role in regulating aging in skin cells. Turns out, during exposure to ultraviolet light, the body increases Complex II SDH in order to control free radicals. The study made another crucial observation - younger skin typically had high levels of Complex II SDH. The old tissue, by contrast, had lower levels of this enzyme.”

The study specifically highlighted detrimental effect that low levels of this enzyme have on fibroblast cells, which are responsible for building collagen.


Given all of the above, it’s not surprising that so many women eventually resort to plastic surgery, regardless of what kind of topical skincare they’ve used in the past. It’s simply unrealistic to expect results on the surface of your skin without addressing changes that are happening internally.

In other words, you need specialized skincare. This is where things get complicated. Menopause has been traditionally overlooked by both, the beauty industry and the medical establishment. In fact, the National Institute of Health still doesn’t a funding category for menopause research. In this environment, most women are facing options that are complex and expensive.


In this environment, a new product from Key Element, LLC, stands out as a bona fide game changer. After focusing on menopause research since 2003, the company released the KeyElement Kit, which addresses signs of skin aging and symptoms of perimenopause in one simple regimen. 

The Kit consists of two concentrated serums and a supplement, all of which contain Agixen® (Sodium Succinate), a proprietary ingredient that targets menopausal changes at a cellular level. 

The supplement promotes energy and hormonal balance, lending powerful natural support against perimenopausal symptoms. The serums deliver the benefits of Axigen® through the skin, along with other clinically proven skincare ingredients.

According to Dr. Krishna, Key Element offers new hope to stave off skin aging during perimenopause thanks to Sodium succinate, which activates succinate dehydrogenase Complex II-SDH enzymes. “As a building block for succinate dehydrogenase, succinate is uniquely positioned to activate Complex II-SDH and unlock its anti-aging potential. This real innovation could help us harness the power of complex II-SDH in order to prevent and reverse signs of skin aging.

You can learn more about The Key Element Kit here